The transcriptional factor Osterix directly interacts with RNA helicase A.
Author: Amorim BR, Okamura H, Yoshida K, Qiu L, Morimoto H, Haneji T.
Affiliation:
Department of Histology and Oral Histology, Institute of Health Biosciences, The University of Tokushima Graduate School, Kuramoto, Tokushima 770-8504, Japan.
Conference/Journal: Biochem Biophys Res Commu
Date published: 2007 Apr 6
Other:
Volume ID: 355 , Issue ID: 2 , Pages: 347-51 , Word Count: 96
Osterix is an osteoblast-specific transcriptional factor, required for bone formation and osteoblast differentiation. Here, we identified new Osterix interacting factors by using matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Among the candidates, RNA helicase A was identified to interact with Osterix. To determine the interaction of Osterix with RNA helicase A, immunoprecipitation assay was performed. Western analysis confirmed the association between Osterix and RNA helicase A. Immunocytochemical analysis also showed that Osterix and RNA helicase A were co-localized in HEK 293 cells. Our data suggest that RNA helicase A might be a component of Osterix regulation.
PMID: 17303075
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