Effect of Exercise Training on Quality of Life, Symptoms, and Functional Status in Advanced-Stage Lung Cancer Patients: A Systematic Review

Author: Tena Nguyen1, Katharine Tracy1, Asad Ullah2, Nagla Abdel Karim3
1 Medical College of Georgia, Augusta University, Augusta, GA 30904, USA.
2 Department of Pathology, Immunology and Microbiology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
3 Inova Schar Cancer Institute, Department of Medicine, University of Virginia, Fairfax, VA 22031, USA.
Conference/Journal: Clin Pract
Date published: 2023 Jun 13
Other: Volume ID: 13 , Issue ID: 3 , Pages: 715-730 , Special Notes: doi: 10.3390/clinpract13030065. , Word Count: 162

Advanced-stage lung cancer (LC) causes significant morbidity and impacts patients' quality of life (QoL). Exercise has been proven to be safe, feasible, and beneficial for symptom reduction and QoL improvement in many types of cancers, but research is limited in advanced-stage LC patients. This systematic review evaluates the effect of exercise interventions on the symptoms and QoL in patients with advanced-stage LC. Twelve prospective studies (744 participants) were included, evaluating different combinations of exercises and training such as aerobics, tai chi, strength, inspiratory muscle training, and relaxation. Studies found outcomes including but not limited to improved QoL, symptom burden, psychosocial health, functional status, and physical function. The results of this review support that exercise is safe and feasible with evidence supporting improved QoL and symptom mitigation. Integration of exercise should be considered in the individualized management of advanced-stage LC patients under the guidance of their healthcare providers.

Keywords: advanced-stage lung cancer; functional status; individualized management; quality of life.

PMID: 37366934 PMCID: PMC10296866 DOI: 10.3390/clinpract13030065