An original biomarker for the risk of developing cardiovascular diseases and their complications: Telomere length

Author: Natalya A Doroschuk1,2, Anton Yu Postnov2,3, Alexander D Doroschuk1,2, Anastasia I Ryzhkova1, Vasily V Sinyov1,2, Marina D Sazonova1, Victoria A Khotina1,3, Alexander N Orekhov1,4,3, Igor A Sobenin1,2, Margarita A Sazonova1,2
1 Institute of General Pathology and Pathophysiology, Laboratory of Angiopathology, 8, Baltiyskaya Str., Moscow, 125315, Russian Federation.
2 National Medical Research Center of Cardiology Ministry of Health Products RF, Laboratory of Medical Genetics, 15a, 3rd Cherepkovskaya Str., Moscow, 121552, Russian Federation.
3 Research Institute of Human Morphology, Laboratory of Cellular and Molecular Pathology of Cardiovascular System, 3, Tsyurupa Street, 117418, Moscow, Russian Federation.
4 Institute for Atherosclerosis Research, Skolkovo Innovative Centre, 100, Novaya Str., Skolkovo village, Odintsovsky District, Moscow Region, 143085, Russian Federation.
Conference/Journal: Toxicol Rep
Date published: 2021 Mar 4
Other: Volume ID: 8 , Pages: 499-504 , Special Notes: doi: 10.1016/j.toxrep.2021.02.024. , Word Count: 163

The aim of this work was to study the effect of telomere length in the chromosomes of nuclear blood cells in individuals with coronary heart disease (CHD) on the development of cardiovascular complications (CVC).

Materials and methods:
DNA was isolated from nuclear blood cells of 498 study participants. The telomere length was determined by real-time polymerase chain reaction. The investigation of each sample was repeated three times. Five years after the end of this study, a telephone survey of 119 patients with CHD was conducted in order to obtain data on the presence of CVC.

According to the results obtained, a decrease in telomere length in patients with coronary heart disease increases the risk of subsequent development of cardiovascular complications.

Patients with coronary heart disease with shorter telomeres compared with conventionally healthy study participants had an increased risk of cardiovascular complications within 5 years after telomere analysis.

Keywords: Aging; Cardiovascular complications; Coronary heart disease; Telomere repeats; Telomeres.

PMID: 33732625 PMCID: PMC7941069 DOI: 10.1016/j.toxrep.2021.02.024