Whole-Body Vibration Training Increases Stem/Progenitor Cell Circulation Levels and May Attenuate Inflammation.

Author: Jawed Y1, Beli E2, March K3, Kaleth A4, Loghmani MT5
1Division of Pulmonary, Critical Care, Sleep and Occupational Medicine, School of Medicine, Indiana University, 541 Clinical Dr., CL 260, Indianapolis, IN 46202.
2Indiana Diabetes Research Center, School of Medicine, Indiana University, 635 Barnhill Dr., MS 2031A, Indianapolis, IN 46202.
3Center for Regenerative Medicine, College of Medicine, University of Florida, M-108 Health Science Center, P.O. Box 100216, Gainesville, FL 32610.
4Department of Kinesiology, School of Health and Human Sciences, Indiana University, 901 W. New York Street, Indianapolis, IN 46202.
5Department of Physical Therapy, School of Health and Human Sciences, Indiana University, 1140 W. Michigan Street, CF320A, Indianapolis, IN 46202.
Conference/Journal: Mil Med.
Date published: 2020 Jan 7
Other: Volume ID: 185 , Issue ID: Supplement_1 , Pages: 404-412 , Special Notes: doi: 10.1093/milmed/usz247. , Word Count: 216

INTRODUCTION: Whole-body vibration training (WBVT) may benefit individuals with difficulty participating in physical exercise. The objective was to explore the effects of WBVT on circulating stem/progenitor cell (CPC) and cytokine levels.

METHODS: Healthy male subjects each performed three activities randomly on separate days: (1) standing platform vibration, (2) repetitive leg squat exercise; and (3) in combination. Pre- and post-activity blood samples were drawn. Cell populations were characterized using flow cytometry. Biomarkers were analyzed using enzyme-linked immunosorbent assays.

RESULTS: CPC levels increased significantly 21% with exercise alone (1465 ± 202-1770 ± 221 cells/mL; P = 0.017) and 33% with vibration alone in younger participants (1918 ± 341-2559 ± 496; P = 0.02). Angiogenic CPCs increased 39% during combined activity in younger (633 ± 128-882 ± 181; P = 0.05). Non-angiogenic CPCs increased 42% with vibration alone in younger (1181 ± 222-1677 ± 342; P = 0.04), but 32% with exercise alone in older participants (801 ± 251-1053 ± 325; P = 0.05). With vibration alone, anti-inflammatory cytokine interleukin-10 increased significantly (P < 0.03), although inflammatory interleukin-6 decreased (P = 0.056); tumor necrosis factor-alpha (P < 0.01) and vascular endothelial growth factor levels increased (P < 0.005), which are synergistically pro-angiogenic.

CONCLUSIONS: WBVT may have positive vascular and anti-inflammatory effects. WBVT could augment or serve as an exercise surrogate in warfighters and others who cannot fully participate in exercise programs, having important implications in military health.

© Association of Military Surgeons of the United States 2020. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

PMID: 32074302 DOI: 10.1093/milmed/usz247