Central Effects of Cranial Nerve Stimulation.
Author: Kohlberg GD1, Samy RN2
Affiliation:
1Division of Otology and Neurotology, Department of Otolaryngology - Head and Neck Surgery, University of Washington School of Medicine, 1959 NE Pacific Street, Box 356161, Seattle, WA 98195 - 6161, USA.
2Division of Otology/Neurotology, Neurotology Fellowship, Department of Otolaryngology - Head and Neck Surgery, University of Cincinnati College of Medicine, Neurosensory Disorders Center at University of Cincinnati Gardner Neuroscience Institute, Cincinnati Children's Hospital Medical Center, 213 Albert Sabin, Way, MSB 6009C, Cincinnati, OH 45267-0528, USA. Electronic address: ravi.samy@uc.edu.
Conference/Journal: Otolaryngol Clin North Am.
Date published: 2019 Oct 21
Other:
Pages: S0030-6665(19)30170-7 , Special Notes: doi: 10.1016/j.otc.2019.09.003. [Epub ahead of print] , Word Count: 121
The current literature on peripheral cranial nerve stimulation for the purpose of achieving therapeutic effects via altering brain activity is reviewed. Vagus nerve stimulation, which is approved for use in refractory epilepsy, is the most extensively studied cranial nerve stimulator that has direct impact on the central nervous system. Despite the recognized central effects of peripheral cranial nerve stimulation, the mechanism of action for all indications remains incompletely understood. Further research on both mechanisms and indications of central effects of cranial nerve stimulation has the potential to alleviate burden of disease in a large array of conditions.
Copyright © 2019 Elsevier Inc. All rights reserved.
KEYWORDS: Central processing; Central reorganization; Cochlear implant; Cortical adaptation; Hearing loss; Vagal nerve stimulation
PMID: 31648824 DOI: 10.1016/j.otc.2019.09.003
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