Effects of low-intensity pulsed ultrasound on soft tissue micro-circulation in the foot.
Author: Kösters AK1, Ganse B1, Gueorguiev B2, Klos K3, Modabber A4, Nebelung S5, Kim BS6, Knobe M7
Affiliation:
1Department of Orthopaedic Trauma, University of Aachen Medical Center, 30 Pauwelsstreet, 52074, Aachen, Germany.
2AO Research Institute Davos, Davos, Switzerland.
3Department of Foot and Ankle Surgery, Catholic Hospital Mainz, Mainz, Germany.
4Department of Oral and Maxillofacial Surgery, University of Aachen Medical Center, Aachen, Germany.
5Department of Radiology, University of Aachen Medical Center, Aachen, Germany.
6Department of Plastic Surgery, Reconstructive and Hand Surgery, University of Aachen Medical Center, Aachen, Germany.
7Department of Orthopaedic Trauma, University of Aachen Medical Center, 30 Pauwelsstreet, 52074, Aachen, Germany. mknobe@ukaachen.de.
Conference/Journal: Int Orthop.
Date published: 2017 Jul 22
Other:
Special Notes: doi: 10.1007/s00264-017-3574-3. [Epub ahead of print] , Word Count: 193
PURPOSE: Low-intensity pulsed ultrasound (LIPUS) has been shown to accelerate bone healing and is considered to increase blood flow. The aim of this study was to assess changes in micro-circulation of the foots' soft tissue in response to LIPUS intervention. We hypothesised improved micro-circulation in response to LIPUS.
METHODS: Micro-circulation was assessed in 2 mm and 8 mm-deep skin of 50 healthy volunteers using non-invasive laser-doppler spectrophotometry (O2C-device). Measurements were performed before LIPUS-intervention (pre), directly after intervention (post) and 20, 40 and 60 minutes after LIPUS.
RESULTS: All parameter of micro-circulation increased directly after LIPUS intervention at 8 mm depth. Participants with a low pre-intervention flow showed the largest changes (p < 0.001) with an increased post-flow of 38%. SO2 levels increased significantly after intervention (p = 0.045) and decreased after 60 minutes in comparison to pre-intervention status. rHb levels after 60 min were significantly higher in comparison to pre-intervention levels.
CONCLUSION: In healthy volunteers, low-intensity pulsed ultrasound led to significant short-term changes in microcirculation of the foot. Younger subjects with a low pre-flow level and smokers showed a higher potential to increase blood flow after LIPUS.
KEYWORDS: Blood flow; Hindfoot; Low-intensity pulsed ultrasound; Micro-circulation; O2C; Soft tissue
PMID: 28735428 DOI: 10.1007/s00264-017-3574-3
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