Comparing the effects of whole-body vibration to standard exercise in ambulatory people with Multiple Sclerosis: A randomised controlled feasibility study.

Author: Uszynski MK1, Purtill H2, Donnelly A3, Coote S4.
1Clinical Therapies Department, University of Limerick, Limerick, Ireland Multiple Sclerosis Society of Ireland, Galway, Ireland 2Department of Mathematics & Statistics, University of Limerick, Limerick, Ireland. 3Physical Education & Sport Sciences Department, University of Limerick, Limerick, Ireland. 4Clinical Therapies Department, University of Limerick, Limerick, Ireland.
Conference/Journal: Clin Rehabil.
Date published: 2015 Jul 27
Other: Word Count: 252

This study aimed firstly to investigate the feasibility of the study protocol and outcome measures, secondly to obtain data in order to inform the power calculations for a larger randomised controlled trial, and finally to investigate if whole-body vibration (WBV) is more effective than the same duration and intensity of standard exercises (EXE) in people with Multiple Sclerosis (PwMS).
Randomised controlled feasibility study.
Outpatient MS centre.
Twenty seven PwMS (age mean (SD) 48.1 (11.2)) with minimal gait impairments.
Twelve weeks of WBV or standard EXE, three times weekly.
Participants were measured with isokinetic muscle strength, vibration threshold, Timed Up and Go test (TUG), Mini-BESTest (MBT), 6 Minute Walk test (6MWT), Multiple Sclerosis Impact Scale 29 (MSIS 29), Modified Fatigue Impact Scale (MFIS) and Verbal Analogue scale for sensation (VAS) pre and post 12 week intervention.
WBV intervention was found feasible with low drop-out rate (11.1%) and high compliance (90%). Data suggest that a sample of 52 in each group would be sufficient to detect a moderate effect size, with 80% power and 5% significance for 6 minute walk test. Large effect sizes in favour of standard exercise were found for vibration threshold at 5th metatarsophalangeal joint and heel (P=0.014, r= 0.5 and P=0.005, r=0.56 respectively). No between group differences were found for muscle strength, balance or gait (P>0.05).
Data suggest that the protocol is feasible, there were no adverse effects. A trial including 120 people would be needed to detect an effect on walking endurance.
© The Author(s) 2015.
Multiple Sclerosis; exercise; mobility; whole-body vibration
PMID: 26219667