Shorter telomere length in peripheral blood leukocytes is associated with childhood autism.

Author: Li Z1, Tang J2, Li H2, Chen S1, He Y2, Liao Y2, Wei Z3, Wan G3, Xiang X4, Xia K5, Chen X6.
Affiliation:
11] Institute of Mental Health, the Second Xiangya Hospital of Central South University, Changsha, Hunan, China [2] Institute of Genomic Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, China. 2Institute of Mental Health, the Second Xiangya Hospital of Central South University, Changsha, Hunan, China. 3Department of Women's Health Care, The Affiliated Shenzhen Maternal and Child Health Care Hospital, Nanfang University of Medical Science, Shenzhen, Guangdong, China. 4BGI Ark Biotechnology Co., Ltd., Shenzhen, Guangdong, China. 5The State Key Laboratory of Medical Genetics, Central South University, Changsha, Hunan, China. 61] Institute of Mental Health, the Second Xiangya Hospital of Central South University, Changsha, Hunan, China [2] The State Key Laboratory of Medical Genetics, Central South University, Changsha, Hunan, China [3] Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan, China [4] National Technology of Institute of Psychiatry, Central South University, Changsha, Hunan, China.
Conference/Journal: Sci Rep.
Date published: 2014 Nov 17
Other: Volume ID: 4 , Pages: 7073 , Word Count: 183



Telomeres are protective chromosomal structures that play a key role in preserving genomic stability. Epidemiologic studies have shown that the abnormal telomere length in leukocytes is associated with some mental disorders and age-related diseases. However, the association between leukocyte telomere length and autism has not been investigated. Here we investigated the possible association between relative telomere length (RTL) in peripheral blood leukocytes and childhood autism by using an established real-time polymerase chain reaction method. We observed significantly shorter RTL in patients with childhood autism than in controls (p = 0.006). Individuals with shorter RTL had a significantly increased presence of childhood autism compared with those who had long RTL. In patients, we found that family training interventions have a significant effect on telomere length (P = 0.012), but no correlations between RTL and clinical features (paternal age, maternal age, age of onset, illness of duration, CARS score and ABC score) were observed in this study. These results provided the first evidence that shorter leukocytes telomere length is significantly associated with childhood autism. The molecular mechanism underlying telomere length may be implicated in the development of autism.
PMID: 25399515

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