Low-intensity pulsed ultrasound enhances cell killing induced by X-irradiation.
Author: Buldakov MA, Feril LB Jr, Tachibana K, Cherdyntseva NV, Kondo T.
Affiliation:
Cancer Research Institute of Tomsk Scientific Center of Siberian Branch of Russian Academy of Medical Science, Tomsk, Russia; Department of Radiological Sciences, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan.
Conference/Journal: Ultrason Sonochem.
Date published: 2013 Jun 27
Other:
Pages: S1350-4177(13)00151-X , Special Notes: doi: 10.1016/j.ultsonch.2013.06.013 , Word Count: 125
To determine the effect of pulsed ultrasound (US) on radiation-induced cell killing, U937 and Molt-4 cell lines were exposed to 1.0MHz US with 50% of duty factor at 0.3W/cm2 and pulsed at 1Hz immediately after exposure to X-rays at 0, 0.5, 2.5 and 5Gy. The cells were assayed 24h after the treatments. The result showed significant enhancement of cell killing in the combined treatments. However, the ratio of apoptotic cells induced either by X-rays or US alone did not significantly change. These findings suggest that pulsed US can enhance the anticancer effect of X-irradiation due to US streaming under non-inertial cavitational condition. This combined treatment can potentially enhance the therapeutic effect of radiation therapy.
Copyright © 2013 Elsevier B.V. All rights reserved.
KEYWORDS:
Apoptosis, Cell killing, Ultrasound, X-rays
PMID: 23835401
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