Controllable in vivo hyperthermia effect induced by pulsed high intensity focused ultrasound with low duty cycles.
Author: Tu J, Ha Hwang J, Chen T, Fan T, Guo X, Crum LA, Zhang D.
Affiliation:
Key Laboratory of Modern Acoustics (Nanjing University), Ministry of Education, Nanjing, Jiangsu 210093, China.
Conference/Journal: Appl Phys Lett.
Date published: 2012 Sep 17
Other:
Volume ID: 101 , Issue ID: 12 , Pages: 124102 , Word Count: 100
High intensity focused ultrasound (HIFU)-induced hyperthermia is a promising tool for cancer therapy. Three-dimensional nonlinear acoustic-bioheat transfer-blood flow-coupling model simulations and in vivo thermocouple measurements were performed to study hyperthermia effects in rabbit auricular vein exposed to pulsed HIFU (pHIFU) at varied duty cycles (DCs). pHIFU-induced temperature elevations are shown to increase with increasing DC. A critical DC of 6.9% is estimated for temperature at distal vessel wall exceeding 44 °C, although different tissue depths and inclusions could affect the DC threshold. The results demonstrate clinic potentials of achieving controllable hyperthermia by adjusting pHIFU DCs, while minimizing perivascular thermal injury.
PMID: 23112347
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