Ultrasound meets nanomedicine: towards disease treatment and medical imaging
Author: Xiaochun Li1, Yanting Liu2, Xuewan Wu2, Rui Huang2, Shaoqi Chen3, Kaisong Yuan4,5
Affiliation:
1 Department of Ultrasound, First Affiliated Hospital of Shantou University Medical College, Shantou, 515041, China.
2 Bio-Analytical Laboratory, Shantou University Medical College, Shantou, 515041, China.
3 Department of Ultrasound, First Affiliated Hospital of Shantou University Medical College, Shantou, 515041, China. chensq@stu.edu.cn.
4 Department of Ultrasound, First Affiliated Hospital of Shantou University Medical College, Shantou, 515041, China. ksyuan@stu.edu.cn.
5 Bio-Analytical Laboratory, Shantou University Medical College, Shantou, 515041, China. ksyuan@stu.edu.cn.
Conference/Journal: Mikrochim Acta
Date published: 2025 Mar 7
Other:
Volume ID: 192 , Issue ID: 4 , Pages: 215 , Special Notes: doi: 10.1007/s00604-025-07042-y. , Word Count: 153
As a kind of mechanical wave, ultrasound has been widely employed in the biomedical field due to its superiors of deep tissue penetration, non-destructiveness and non-toxicity. In this review, we highlight current progress and prospects in using ultrasound as a powerful tool for disease treatment and medical imaging, including (1) ultrasound as energy input for driving nano/micromotor in drug delivery, this part first introduces the synthesis and motion behavior of nano/micromotors, then reviews the small molecular and macromolecular compounds that the nano/micromotors are delivering; (2) sonosensitive nanomaterials for disease therapy, the sonodynamic, sonopiezoelectric, sonothermal, and sonomechanical therapy will all be covered; (3) ultrasound as a non-invasive technique for nano/micromotor tracking or medical imaging; (4) the sonoporation of nano/microbubble. Future challenges in using ultrasound for disease treatment or medical imaging will also be described in the conclusion part.
Keywords: Nano/micromotor; Sonosensitive nanomaterials; Ultrasound imaging; Ultrasound propulsion.
PMID: 40053162 DOI: 10.1007/s00604-025-07042-y
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