Author: M Costa1, A A Priplata, L A Lipsitz, Z Wu, N E Huang, A L Goldberger, C-K Peng
1 Division of Interdisciplinary Medicine and Biotechnology, Beth Israel Deaconess Medical Center, Harvard Medical School - 330 Brookline Avenue, Boston, MA 02215, USA.
Conference/Journal: Europhys Lett
Date published: 2007 Mar 1
Other: Volume ID: 77 , Pages: 68008 , Special Notes: doi: 10.1209/0295-5075/77/68008. , Word Count: 123
Pathologic states are associated with a loss of dynamical complexity. Therefore, therapeutic interventions that increase physiologic complexity may enhance health status. Using multiscale entropy analysis, we show that the postural sway dynamics of healthy young and healthy elderly subjects are more complex than that of elderly subjects with a history of falls. Application of subsensory noise to the feet has been demonstrated to improve postural stability in the elderly. We next show that this therapy significantly increases the multiscale complexity of sway fluctuations in healthy elderly subjects. Quantification of changes in dynamical complexity of biologic variability may be the basis of a new approach to assessing risk and to predicting the efficacy of clinical interventions, including noise-based therapies.
PMID: 17710211 PMCID: PMC1949396 DOI: 10.1209/0295-5075/77/68008