Telomeres: history, health, and hallmarks of aging
Author: Deepavali Chakravarti1, Kyle A LaBella1, Ronald A DePinho2
Affiliation:
1 Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
2 Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: rdepinho@mdanderson.org.
Conference/Journal: Cell
Date published: 2021 Jan 7
Other:
Special Notes: doi: 10.1016/j.cell.2020.12.028. , Word Count: 106
The escalating social and economic burden of an aging world population has placed aging research at center stage. The hallmarks of aging comprise diverse molecular mechanisms and cellular systems that are interrelated and act in concert to drive the aging process. Here, through the lens of telomere biology, we examine how telomere dysfunction may amplify or drive molecular biological processes underlying each hallmark of aging and contribute to development of age-related diseases such as neurodegeneration and cancer. The intimate link of telomeres to aging hallmarks informs preventive and therapeutic interventions designed to attenuate aging itself and reduce the incidence of age-associated diseases.
PMID: 33450206 DOI: 10.1016/j.cell.2020.12.028
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