Interoception and Mental Health: A Roadmap.

Author: Khalsa SS1, Adolphs R2, Cameron OG3, Critchley HD4, Davenport PW5, Feinstein JS6, Feusner JD7, Garfinkel SN4, Lane RD8, Mehling WE9, Meuret AE10, Nemeroff CB11, Oppenheimer S12, Petzschner FH13, Pollatos O14, Rhudy JL15, Schramm LP16, Simmons WK6, Stein MB17, Stephan KE13, Van den Bergh O18, Van Diest I18, von Leupoldt A18, Paulus MP, Interoception Summit 2016 participants
Affiliation:
1Laureate Institute for Brain Research, University of Tulsa, Tulsa, Oklahoma; Oxley College of Health Sciences, University of Tulsa, Tulsa, Oklahoma. Electronic address: skhalsa@laureateinstitute.org.
2California Institute of Technology, Pasadena, California.
3Department of Psychiatry, University of Michigan, Ann Arbor, Michigan.
4Sackler Centre for Consciousness Science, University of Sussex, Brighton, United Kingdom.
5Department of Physiology, University of Florida, Gainesville, Florida.
6Laureate Institute for Brain Research, University of Tulsa, Tulsa, Oklahoma; Oxley College of Health Sciences, University of Tulsa, Tulsa, Oklahoma.
7Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, California.
8Department of Psychiatry, University of Arizona, Tucson, Arizona.
9Department of Family and Community Medicine, University of California, San Francisco, San Francisco, California.
10Department of Psychology, Southern Methodist University, Dallas, Texas.
11Department of Psychiatry and Behavioral Sciences, University of Miami, Miami, Florida.
12Department of Neurology, Johns Hopkins University, Baltimore, Maryland.
13Translational Neuromodeling Unit, Institute for Biomedical Engineering, University of Zurich, Zurich, Switzerland.
14Department of Clinical and Health Psychology, Institute of Psychology and Education, Ulm University, Ulm, Germany.
15Department of Psychology, University of Tulsa, Tulsa, Oklahoma.
16Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland; Department of Neuroscience, Johns Hopkins University, Baltimore, Maryland.
17Department of Psychiatry, University of California, San Diego, San Diego, California.
18Department of Health Psychology, University of Leuven, Leuven, Belgium.
19Laureate Institute for Brain Research, University of Tulsa, Tulsa, Oklahoma.
Conference/Journal: Biol Psychiatry Cogn Neurosci Neuroimaging.
Date published: 2018 Jun
Other: Volume ID: 3 , Issue ID: 6 , Pages: 501-513 , Special Notes: doi: 10.1016/j.bpsc.2017.12.004. Epub 2017 Dec 28. , Word Count: 218


Interoception refers to the process by which the nervous system senses, interprets, and integrates signals originating from within the body, providing a moment-by-moment mapping of the body's internal landscape across conscious and unconscious levels. Interoceptive signaling has been considered a component process of reflexes, urges, feelings, drives, adaptive responses, and cognitive and emotional experiences, highlighting its contributions to the maintenance of homeostatic functioning, body regulation, and survival. Dysfunction of interoception is increasingly recognized as an important component of different mental health conditions, including anxiety disorders, mood disorders, eating disorders, addictive disorders, and somatic symptom disorders. However, a number of conceptual and methodological challenges have made it difficult for interoceptive constructs to be broadly applied in mental health research and treatment settings. In November 2016, the Laureate Institute for Brain Research organized the first Interoception Summit, a gathering of interoception experts from around the world, with the goal of accelerating progress in understanding the role of interoception in mental health. The discussions at the meeting were organized around four themes: interoceptive assessment, interoceptive integration, interoceptive psychopathology, and the generation of a roadmap that could serve as a guide for future endeavors. This review article presents an overview of the emerging consensus generated by the meeting.

KEYWORDS: Biomarker; Computational psychiatry; Interoception; Mental health; Research Domain Criteria; Treatment

PMID: 29884281 DOI: 10.1016/j.bpsc.2017.12.004

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