Exercise for Toxicity Management in Cancer-A Narrative Review.

Author: Kleckner IR1, Dunne RF1, Asare M1, Cole C1, Fleming F1, Fung C1, Lin PJ1, Mustian KM1
Author Information:
1University of Rochester Medical Center, James P Wilmot Cancer Institute, Rochester, NY, US.
Conference/Journal: Oncol Hematol Rev.
Date published: 2018 Spring
Other: Volume ID: 14 , Issue ID: 1 , Pages: 28-37 , Word Count: 191

Although the treatment of cancer is more effective now than ever, patients with cancer still face acute and chronic toxicities such as fatigue, cardiotoxicity, pain, cognitive impairment, and neurotoxicity. In this narrative review, we briefly discuss the use of exercise for toxicity management in patients with cancer, biological mechanisms underlying the toxicities and the effects of exercise, barriers that patients- especially underserved patients-face in adopting and adhering to exercise programs, and new technologies to overcome barriers to exercise. Our conclusions and clinical suggestions are: (1) exercise is safe and effective for treating many toxicities; (2) patients can benefit from a variety of exercise modalities (e.g., walking, cycling, resistance bands, yoga); (3) exercise should be started as soon as possible, even before treatments begin; (4) exercise should be continued as long as possible, as a lifestyle; and (5) barriers to exercise should be identified and addressed, (e.g., continually encouraging patients to exercise, using mobile technology, advocating for safe communities that encourage active lifestyles). Future research should inform definitive clinical guidelines for the use of exercise to ameliorate toxicities from cancer and its treatment.

KEYWORDS: Side effects; Tai Chi; disparities; exercise; mHealth; mechanism; toxicities; yoga

PMID: 29713475