The Application of Pulsed Electromagnetic Fields (PEMFs) for Bone Fracture Repair: Past and Perspective Findings.
Author: Daish C1,2, Blanchard R3, Fox K4, Pivonka P5, Pirogova E4
Affiliation:
1Electrical and Biomedical Engineering, School of Engineering, RMIT University, Melbourne, VIC, 3000, Australia. christian.daish@gmail.com.
2St Vincent's Department of Surgery, The University of Melbourne, Fitzroy, VIC, 3065, Australia. christian.daish@gmail.com.
3St Vincent's Department of Surgery, The University of Melbourne, Fitzroy, VIC, 3065, Australia.
4Electrical and Biomedical Engineering, School of Engineering, RMIT University, Melbourne, VIC, 3000, Australia.
5School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology, Brisbane, QLD, 4000, Australia.
Conference/Journal: Ann Biomed Eng.
Date published: 2018 Jan 22
Other:
Special Notes: doi: 10.1007/s10439-018-1982-1. [Epub ahead of print] , Word Count: 208
Bone fractures are one of the most commonly occurring injuries of the musculoskeletal system. A highly complex physiological process, fracture healing has been studied extensively. Data from in vivo, in vitro and clinical studies, have shown pulsed electromagnetic fields (PEMFs) to be highly influential in the fracture repair process. Whilst the underlying mechanisms acting to either inhibit or advance the physiological processes are yet to be defined conclusively, several non-invasive point of use devices have been developed for the clinical treatment of fractures. With the complexity of the repair process, involving many components acting at different time steps, it has been a challenge to determine which PEMF exposure parameters (i.e., frequency of field, intensity of field and dose) will produce the most optimal repair. In addition, the development of an evidence-backed device comes with challenges of its own, with many elements (including process of exposure, construct materials and tissue densities) being highly influential to the field exposed. The objective of this review is to provide a broad recount of the applications of PEMFs in bone fracture repair and to then demonstrate what is further required for enhanced therapeutic outcomes.
KEYWORDS: Bone repair; Cell scale; Clinical devices; Computational modeling; Review; Tissue scale
PMID: 29356996 DOI: 10.1007/s10439-018-1982-1
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