Effects of Acupuncture Treatment on Fibromyalgia Symptoms, Serotonin, and Substance P Levels: A Randomized Sham and Placebo-Controlled Clinical Trial.
Author: Karatay S1, Okur SC2, Uzkeser H3, Yildirim K3, Akcay F4
Affiliation:
1Health Science Faculty, Department of Physiotherapy and Rehabilitation, Gazi University, Ankara, Turkey.
2Department of Physical Medicine and Rehabilitation, Ministry of Health, Istanbul Training and Research Hospital, Istanbul, Turkey.
3Department of Physical Medicine and Rehabilitation, Ataturk University, Medical Faculty, Erzurum, Turkey.
4Department of Biochemistry, Ataturk University, Medical Faculty, Erzurum, Turkey.
Conference/Journal: Pain Med.
Date published: 2017 Dec 6
Other:
Special Notes: doi: 10.1093/pm/pnx263. [Epub ahead of print] , Word Count: 298
Objective: The aim of this study was to evaluate the effects of acupuncture treatment on serum levels of serotonin and substance P (SP) as well as on clinical parameters in patients with fibromyalgia (FM).
Methods: This is a randomized controlled clinical trial. Seventy-five women with FM were randomized into one of three kinds of acupuncture treatment: real acupuncture group (AcG), sham acupuncture group (ShG), and simulated acupuncture group (SiG). Treatments were applied semiweekly for four weeks. The serum levels of serotonin and SP were evaluated before and after the eight sessions. Patients were clinically assessed by visual analog scale (VAS), the number of tender points (NTP), Fibromyalgia Impact Questionnaire (FIQ), Beck Depression Inventory (BDI), and Nottingham Health Profile (NHP) at baseline, after the last treatment, and one and three months after completion of all treatments.
Results: Serum serotonin values increased significantly after treatment in AcG and ShG (P < 0.001 and P < 0.01, respectively). The increase in the AcG was also different from both of the other groups (P < 0.01). While SP levels decreased in the AcG, they increased in the SiG (P = 0.001). In the AcG, significant improvements were found in almost all clinical outcomes after treatment. These usually continued for three months. In the ShG, there were also significant changes on the NTP, VAS, FIQ, and BDI scores after treatment. Improvements on the NTP and FIQ scores lasted for three months. In the SiG, significant improvements were found only in the NTP, VAS, and BDI scores after treatment.
Conclusions: Acupuncture, rather than sham or placebo acupuncture, may lead to long-term improvements on clinical outcomes and pain neuromediator values. Changes in serum serotonin and SP levels may be a valuable explanation for acupuncture mechanisms in FM treatment.
KEYWORDS: Acupuncture; Fibromyalgia; Pain; Serotonin; Substance P; Treatment
PMID: 29220534 DOI: 10.1093/pm/pnx263
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