Low-Frequency Pulsed Electromagnetic Field Is Able to Modulate miRNAs in an Experimental Cell Model of Alzheimer's Disease

Author: Capelli E1,2, Torrisi F1,2, Venturini L3, Granato M1,2, Fassina L2,4, Lupo GFD1,2, Ricevuti G3
1Department of Earth and Environmental Sciences, Section of Animal Biology, University of Pavia, Via Taramelli 24, 27100 Pavia, Italy
2Centre for Health Technologies (C.H.T.), University of Pavia, Via Ferrata 1, 27100 Pavia, Italy
3Department of Internal Medicine and Therapeutics, Section of Geriatrics and Gerontology, IDR “Santa Margherita”, University of Pavia, Via Emilia 12, 27100 Pavia, Italy
4Department of Electrical, Computer and Biomedical Engineering, University of Pavia, Via Ferrata 1, 27100 Pavia, Italy
Conference/Journal: J Healthc Eng.
Date published: 2017
Other: Volume ID: 2017 , Special Notes: doi: 10.1155/2017/2530270. , Word Count: 156

The aim of the present study was to investigate on the effects of a low-frequency pulsed electromagnetic field (LF-PEMF) in an experimental cell model of Alzheimer's disease (AD) to assess new therapies that counteract neurodegeneration. In recent scientific literature, it is documented that the deep brain stimulation via electromagnetic fields (EMFs) modulates the neurophysiological activity of the pathological circuits and produces clinical benefits in AD patients. EMFs are applied for tissue regeneration because of their ability to stimulate cell proliferation and immune functions via the HSP70 protein family. However, the effects of EMFs are still controversial and further investigations are required. Our results demonstrate the ability of our LF-PEMF to modulate gene expression in cell functions that are dysregulated in AD (i.e., BACE1) and that these effects can be modulated with different treatment conditions. Of relevance, we will focus on miRNAs regulating the pathways involved in brain degenerative disorders.

© 2017 Enrica Capelli et al.

PMID: 29072895 DOI: 10.1155/2017/2530270