Low-intensity Pulsed Ultrasound Stimulation for Tendon-Bone Healing: A Dose-dependent Study.
Author: Lu H1, Liu F, Chen C, Wang Z, Chen H, Qu J, Zhang T, Xu D, Hu J
Affiliation:
11Department of Sports Medicine, Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Research Center of Sports Medicine, Xiangya Hospital, Central South University. 2Department of Spine Surgery, Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Research Center of Sports Medicine, Xiangya Hospital, Central South University.
Conference/Journal: Am J Phys Med Rehabil.
Date published: 2017 Oct 7
Other:
Special Notes: doi: 10.1097/PHM.0000000000000844. [Epub ahead of print] , Word Count: 176
OBJECTIVES: This study aimed to evaluate the dosage effect of low-intensity pulsed ultrasound stimulation (LIPUS) on tendon-bone (T-B) healing.
DESIGN: Standard partial patellectomies were performed on 120 mature New Zealand rabbits randomly assigned into three groups: a control group (daily mock sonication, 20 min), a qd group (daily ultra-sonication, 20 min), and a bid group (ultra-sonication twice a day, 20 min each time). The rabbits were sacrificed 8 or 16 weeks postoperatively, and the microarchitectural, histological, and mechanical properties of the patella-patellar tendon (PPT) interface were evaluated.
RESULTS: Micro-computed tomography analysis showed that the bid group exhibited more new bone formation and mineralization than the other groups in the T-B healing position at both 8 and 16 weeks postoperatively. Histological assessments confirmed the bid group exhibited a significantly better PPT interface than the other groups, as shown by the increased formation and remodeling of newly formed bone and a fibrocartilage layer. The biomechanical properties of the regenerated PPT interface significantly improved in the bid group.
CONCLUSIONS: LIPUS treatment twice a day was more effective than the once-a-day treatment on tendon-bone healing.
PMID: 29016398 DOI: 10.1097/PHM.0000000000000844
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