Route of placebo administration: Robust placebo effects in laboratory and clinical settings.

Author: Liu T1
Author Information:
1Medical Research Center, Second Teaching Hospital, University of Jilin Norman, Bethune School of Medicine, Changchun, China. Electronic address:
Conference/Journal: Neurosci Biobehav Rev.
Date published: 2017 Sep 21
Other: Pages: S0149-7634(17)30174-4 , Special Notes: doi: 10.1016/j.neubiorev.2017.09.018. [Epub ahead of print] , Word Count: 104

Recent advances in laboratory and clinical research have greatly enhanced our understanding of placebo effects. However, little progress has been made in translational research that can well integrate these findings. This article examines pivotal role of placebo administration in subsequent placebo responses, providing a unified framework that accounts for robust placebo effects in both laboratory and clinical settings.

Copyright © 2017 Elsevier Ltd. All rights reserved.

KEYWORDS: Acupuncture; Anxiety; Appetitive motivation; Belief; Brain mechanisms; Clinical practice; Conditioning; Descending pain modulation; Emotion; Invasive placebo; Learning; Pain; Pain anticipation; Placebo administration; Placebo effects; RCTs; Reward expectation; Route of administration; Sham invasive procedure; Verbal suggestion

PMID: 28941577 DOI: 10.1016/j.neubiorev.2017.09.018