Short-term effects of an intensive lifestyle modification program on lipid peroxidation and antioxidant systems in patients with coronary artery disease

Author: Jatuporn S//Sangwatanaroj S//Saengsiri AO//Rattanapruks S////
Affiliation: Department of Biochemistry, King Chulalongkorn Memorial Hospital, Bangkok, Thailand. srisakul.j@chula.ac.th
Conference/Journal: Clin Hemorheol Microcirc
Date published: 2003
Other: Volume ID: 29 , Issue ID: 3-4 , Pages: 429-36 , Word Count: 153


The purpose of this study was to compare the short-term effects of an intensive lifestyle modification (ILM) program on lipid peroxidation and antioxidant systems in patients with coronary artery disease (CAD). Twenty-two patients in the control group continued to receive their conventional treatment with lipid-lowering drugs, whereas 22 patients in the experimental group were assigned to intensive lifestyle modification (ILM) without taking any lipid-lowering agent. The ILM program comprised dietary advice on low-fat diets, high antioxidants and high fiber intakes, yoga exercise, stress management and smoking cessation. After 4 months of intervention, patients in the experimental group revealed a statistically significant increase in plasma total antioxidants, plasma vitamin E and erythrocyte glutathione (GSH) compared to patients in the control group. There was no significant change in plasma malondialdehyde (MDA), a circulating product of lipid peroxidation, in either group. We concluded that the ILM program increased circulating antioxidants and reduced oxidative stress in patients with CAD.