Cracking Brain Diseases from Gut Microbes-Mediated Metabolites for Precise Treatment

Author: Ying Gong1,2, Anmei Chen1, Guohui Zhang3, Qing Shen2, Liang Zou4, Jiahong Li2, Yang-Bao Miao1, Weixin Liu3
Affiliation: <sup>1</sup> Department of Haematology, Sichuan Academy of Medical Sciences &amp; Sichuan Provincial People&#x27;s Hospital, School of Medicine of University of Electronic Science and Technology of China, No. 32, West Section 2, First Ring Road, Qingyang District, Chengdu 610000, China. <sup>2</sup> School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610041, China. <sup>3</sup> Key Laboratory of reproductive medicine, Sichuan Provincial maternity and Child Health Care Hospital, Chengdu 610000, China. <sup>4</sup> School of Food and Biological Engineering, Chengdu University, Chengdu 610106, Sichuan, China.
Conference/Journal: Int J Biol Sci
Date published: 2023 Jun 4
Other: Volume ID: 19 , Issue ID: 10 , Pages: 2974-2998 , Special Notes: doi: 10.7150/ijbs.85259. , Word Count: 161

The gut-brain axis has been a subject of significant interest in recent years. Understanding the link between the gut and brain axis is crucial for the treatment of disorders. Here, the intricate components and unique relationship between gut microbiota-derived metabolites and the brain are explained in detail. Additionally, the association between gut microbiota-derived metabolites and the integrity of the blood-brain barrier and brain health is emphasized. Meanwhile, gut microbiota-derived metabolites with their recent applications, challenges and opportunities their pathways on different disease treatment are focus discussed. The prospective strategy of gut microbiota-derived metabolites potential applies to the brain disease treatments, such as Parkinson's disease and Alzheimer's disease, is proposed. This review provides a broad perspective on gut microbiota-derived metabolites characteristics facilitate understand the connection between gut and brain and pave the way for the development of a new medication delivery system for gut microbiota-derived metabolites.

Keywords: Gut Microbes; Gut to Brain; Immune System; Metabolites; Vagus Nerve.

PMID: 37416776 PMCID: PMC10321288 DOI: 10.7150/ijbs.85259