Intracranial source activity (eLORETA) related to scalp-level asymmetry scores and depression status.

Author: Smith EE1, Cavanagh JF2, Allen JJB1
Affiliation: <sup>1</sup>Department of Psychology, University of Arizona, Tucson, Arizona, USA. <sup>2</sup>Department of Psychology, University of New Mexico, Albuquerque, New Mexico, USA.
Conference/Journal: Psychophysiology.
Date published: 2017 Oct 11
Other: Special Notes: doi: 10.1111/psyp.13019. [Epub ahead of print] , Word Count: 159

Frontal EEG alpha asymmetry provides a promising index of depression risk, yet very little is known about the neural sources of alpha asymmetry. To identify these sources, this study examined alpha asymmetry using a distributed inverse solution: exact low resolution brain electromagnetic tomography (eLORETA). Findings implicated a generator in lateral midfrontal regions that contributed to both surface asymmetry and depression risk. Participants with any lifetime history of depressive episodes were characterized by less left than right activity in the precentral gyrus and midfrontal gyrus. Anhedonia accounted for a significant portion of the relationship between alpha asymmetry and lifetime major depressive disorder. Results are suggestive of convergence between motivational and capability models of asymmetry and replicate results from experimental studies in a large resting-state data set. The capability model of frontal alpha asymmetry is contextualized in terms of motor preparedness following emotional mobilization.

© 2017 Society for Psychophysiological Research.

KEYWORDS: EEG alpha asymmetry; anhedonia; depression; eLORETA; emotion; source estimation

PMID: 29023805 DOI: 10.1111/psyp.13019