Controllable in vivo hyperthermia effect induced by pulsed high intensity focused ultrasound with low duty cycles. 


Author: Tu J, Ha Hwang J, Chen T, Fan T, Guo X, Crum LA, Zhang D.

Affiliation: Key Laboratory of Modern Acoustics (Nanjing University), Ministry of Education, Nanjing, Jiangsu 210093, China. 
Conference/Journal: Appl Phys Lett. 
Date published: 2012 Sep 17
Other:
 Volume ID: 101   ,  Issue ID: 12   ,  Pages: 124102   ,  Word Count: 100  
    

High intensity focused ultrasound (HIFU)-induced hyperthermia is a promising tool for cancer therapy. Three-dimensional nonlinear acoustic-bioheat transfer-blood flow-coupling model simulations and in vivo thermocouple measurements were performed to study hyperthermia effects in rabbit auricular vein exposed to pulsed HIFU (pHIFU) at varied duty cycles (DCs). pHIFU-induced temperature elevations are shown to increase with increasing DC. A critical DC of 6.9% is estimated for temperature at distal vessel wall exceeding 44 °C, although different tissue depths and inclusions could affect the DC threshold. The results demonstrate clinic potentials of achieving controllable hyperthermia by adjusting pHIFU DCs, while minimizing perivascular thermal injury.

PMID: 23112347