Human psychoneuroimmunology: 20 years of discovery


Author: Michael R Irwin1

Affiliation: <sup>1</sup> Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience, University of California, 300 Medical Plaza, Suite 3-109, Los Angeles, CA 90095-7057, USA. mirwin1@ucla.edu
Conference/Journal: Brain Behav Immun
Date published: 2008 Feb 1
Other:
 Volume ID: 22   ,  Issue ID: 2   ,  Pages: 129-39   ,  Special Notes: doi: 10.1016/j.bbi.2007.07.013.   ,  Word Count: 126  
    An important component of psychoneuroimmunology research is to reveal the myriad ways that behaviors and health are inter-related, with a focus on the immunological mechanisms that underlie these interactions. Research in human psychoneuroimmunology has shown that immunoregulatory processes are an integral part of a complex network of adaptive responses. As such, this review provides a perspective from our laboratory over the last 20 years to define the inter-relationships between behavior and immunity; to identify the hypothalamic pituitary adrenal (HPA) and autonomic mechanisms that link the central nervous system and immune responses; to examine the clinical implications of immune alterations during depression or life stress on inflammatory and infectious disease risk; and to explore the reciprocal role of immune mediators on behavior in humans.





PMID: 17911004 DOI: 10.1016/j.bbi.2007.07.013