Resting-state fMRI Functional Connectivity and Mindfulness in Clinical and Non-clinical Contexts: A Review and Synthesis Author: Idil Sezer1, Diego A Pizzagalli2, Matthew D Sacchet3 Affiliation: <sup>1</sup> Center for Depression, Anxiety, and Stress Research, McLean Hospital, Harvard Medical School, Belmont, MA, USA; Paris Brain Institute, Sorbonne University/CNRS/INSERM, Paris, France. Electronic address: idilsezer1@gmail.com. <sup>2</sup> Center for Depression, Anxiety, and Stress Research, McLean Hospital, Harvard Medical School, Belmont, MA, USA; McLean Imaging Center, McLean Hospital, Belmont, MA, USA. Electronic address: dap@mclean.harvard.edu. <sup>3</sup> Center for Depression, Anxiety, and Stress Research, McLean Hospital, Harvard Medical School, Belmont, MA, USA. Electronic address: msacchet@mclean.harvard.edu. Conference/Journal: Neurosci Biobehav Rev Date published: 2022 Feb 21 Other: Special Notes: doi: 10.1016/j.neubiorev.2022.104583. , Word Count: 194 This review synthesizes relations between mindfulness and resting-state fMRI functional connectivity of brain networks. Mindfulness is characterized by present-moment awareness and experiential acceptance, and relies on attention control, self-awareness, and emotion regulation. We integrate studies of functional connectivity and (1) trait mindfulness and (2) mindfulness meditation interventions. Mindfulness is related to functional connectivity in the default mode (DMN), frontoparietal (FPN), and salience (SN) networks. Specifically, mindfulness-mediated functional connectivity changes include (1) increased connectivity between posterior cingulate cortex (DMN) and dorsolateral prefrontal cortex (FPN), which may relate to attention control; (2) decreased connectivity between cuneus and SN, which may relate to self-awareness; (3) increased connectivity between rostral anterior cingulate cortex region and dorsomedial prefrontal cortex (DMN) and decreased connectivity between rostral anterior cingulate cortex region and amygdala region, both of which may relate to emotion regulation; and lastly, (4) increased connectivity between dorsal anterior cingulate cortex (SN) and anterior insula (SN) which may relate to pain relief. While further study of mindfulness is needed, neural signatures of mindfulness are emerging. Keywords: MBSR; Meditation; Mindfulness; anterior cingulate cortex; attention control; cuneus; default mode network; emotion regulation; frontoparietal network; functional connectivity; posterior cingulate cortex; resting-state fMRI; salience network; self-awareness. PMID: 35202647 DOI: 10.1016/j.neubiorev.2022.104583