The Beneficial Effects of Mind-body Exercises for People with Mild Cognitive Impairment: A Systematic Review with Meta-Analysis. Author: Zou L1, Loprinzi PD2, Yeung AS3, Zeng N4, Huang T5 Affiliation: <sup>1</sup>Department of Sports Science and Physical Education, The Chinese University of Hong Kong, Shatin, Hong Kong, China. Electronic address: liyezou123@gmail.com. <sup>2</sup>Exercise &amp; Memory Laboratory, Department of Health, Exercise Science and Recreation Management, The University of Mississippi, University, MS 38677, USA. <sup>3</sup>Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical, School, Boston, MA 02114, USA. <sup>4</sup>Department of Food Science and Human Nutrition, Colorado State University, CO 80523, USA. <sup>5</sup>Department of Physical Education, Shanghai Jiaotong University, Shanghai, 200000, China. Conference/Journal: Arch Phys Med Rehabil. Date published: 2019 Apr 12 Other: Pages: S0003-9993(19)30239-4 , Special Notes: doi: 10.1016/j.apmr.2019.03.009. [Epub ahead of print] , Word Count: 228 OBJECTIVE: To objectively evaluate the most common forms of mind body exercise (MBE) (Tai Chi, Yoga, and Qigong) on cognitive function among people with MCI. DATA SOURCES: We searched six electronic databases (Scopus, PubMed, PsycINFO, WanFang, Web of Science, and CNKI) from inception until September, 2018. STUDY SELECTION: Nine randomized controlled trials and three non-randomized controlled trials were included for meta-analysis. DATA EXTRACTION: Two researchers independently performed the literature searches, study selection, data extraction, and methodological quality assessment using the revised Physiotherapy Evidence Database (PEDro) scale. DATA SYNTHESIS: The pooled effect size (standardized mean difference, SMD) was calculated while random-effect model was selected. Overall results of the meta-analysis (N = 1298 people with MCI) indicated that MBE significantly improved attention (SMD = 0.39, 95% CI 0.07 to 0.71, p = 0.02, I2 = 31.6%, N = 245), short-term memory (SMD = 0.74, 95% CI 0.57 to 0.90, p < 0.001, I2 = 0%, N = 861), executive function (SMD = -0.42, 95% CI -0.63 to -0.21, p < 0.001, I2 = 38.54%, N = 701), visual-spatial/executive function (SMD = 0.35, 95% CI 0.07 to 0.64, p < 0.05, I2 = 0%, N = 285), and global cognitive function (SMD = 0.36, 95% CI 0.2 to 0.52, p < 0.001, I2 = 15.12%, N = 902). However, the significant positive effect on cognitive processing speed was not observed following MBE interventions (SMD = 0.31, 95% CI -0.01 to 0.63, p = 0.054, I2 = 28.66%, N = 233). CONCLUSIONS: Study findings of this meta-analysis suggest that MBE have the potential to improve various cognitive functions in people with MCI. Copyright © 2019. Published by Elsevier Inc. KEYWORDS: MCI; Mind-body exercise; Qigong; Tai Chi; Yoga; mild cognitive impairment PMID: 30986409 DOI: 10.1016/j.apmr.2019.03.009