The Effects of Movement-to-Music (M2M) and Adapted Yoga on Physical and Psychosocial Outcomes in People with Multiple Sclerosis. Author: Young HJ1, Mehta TS2, Herman C3, Wang F3, Rimmer JH3 Affiliation: <sup>1</sup>UAB/Lakeshore Research Collaborative, School of Health Professions, University of Alabama at Birmingham, Birmingham, AL 35233; Department of Physical Therapy, School of Health Professions, University of Alabama at Birmingham, Birmingham, AL 35233. Electronic address: hjyoung@uab.edu. <sup>2</sup>UAB/Lakeshore Research Collaborative, School of Health Professions, University of Alabama at Birmingham, Birmingham, AL 35233; Department of Health Services Administration, School of Health Professions, University of Alabama at Birmingham, Birmingham, AL 35233. <sup>3</sup>UAB/Lakeshore Research Collaborative, School of Health Professions, University of Alabama at Birmingham, Birmingham, AL 35233. Conference/Journal: Arch Phys Med Rehabil. Date published: 2018 Aug 6 Other: Pages: S0003-9993(18)30924-9 , Special Notes: doi: 10.1016/j.apmr.2018.06.032. [Epub ahead of print] , Word Count: 279 OBJECTIVE: To investigate the effects of two 12-week exercise training interventions, movement-to-music (M2M) and adapted yoga (AY), on physical and psychosocial outcomes in people with multiple sclerosis (MS). DESIGN: Three-arm randomized controlled proof-of-concept trial. SETTING: A community-based fitness facility. PARTICIPANTS: Participants (N=81) with MS (Patient Determined Disease Steps [PDDS] self-reported disease status scores: 0-6) between ages of 18 and 65 years were randomized to: M2M (n=27), AY (n=26), or waitlist control (n=28). INTERVENTIONS: Both M2M and AY completed three 60-minute exercise sessions per week for 12 weeks. Waitlist controls received biweekly newsletters via mail that contained educational information on living with MS. MAIN OUTCOME MEASURES: Primary measures were Timed Up and Go (TUG, seconds), Six-minute Walk Test (6MWT, meters), and Five Times Sit-to-Stand Test (FTSST, seconds). Secondary measures were self-reported outcomes assessed using PROMIS Fatigue and Pain Interference Short Form 8a. Participants were evaluated at baseline and post-intervention. Primary analyses were performed using an intent-to-treat mixed model ANCOVA. RESULTS: Comparisons across all three groups revealed significant group differences in TUG and 6MWT. Post hoc analyses indicated significant improvements in TUG (LSM difference [95% CI]=-1.9s [-3.3, -0.5], p=0.01, d=0.7) and 6MWT (41.0m [2.2, 80.0], p=0.04, d=0.6; controlled for PDDS) in M2M compared to controls, while no significant differences were observed when compared AY to controls. No significant group differences were found on FTSST, fatigue and pain interference. CONCLUSION: Movement-to-music may be a useful and enjoyable exercise form for people with MS in improving mobility and walking endurance and merits long-term study in larger study populations. Copyright © 2018 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved. KEYWORDS: Balance; Mobility; Movement-to-music; Multiple sclerosis; Walking endurance PMID: 30092206 DOI: 10.1016/j.apmr.2018.06.032